WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=4; E=0.48; R=8.41; rawP=0.0014; adjP=0.0076
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
2  ENSG00000136738 NA STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 8027 ENSG00000136738
3  ENSG00000067606 NA PRKCZ protein kinase C, zeta 5590 ENSG00000067606
4  ENSG00000079805 NA DNM2 dynamin 2 1785 ENSG00000079805


Database:KEGG pathway       Name:Pancreatic secretion       ID:04972
C=101; O=3; E=0.24; R=12.56; rawP=0.0018; adjP=0.0076
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
2  ENSG00000132681 NA ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 480 ENSG00000132681
3  ENSG00000138308 NA PLA2G12B phospholipase A2, group XIIB 84647 ENSG00000138308


Database:KEGG pathway       Name:Glycerophospholipid metabolism       ID:00564
C=80; O=3; E=0.19; R=15.86; rawP=0.0009; adjP=0.0076
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000111684 NA LPCAT3 lysophosphatidylcholine acyltransferase 3 10162 ENSG00000111684
2  ENSG00000160216 NA AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 56894 ENSG00000160216
3  ENSG00000138308 NA PLA2G12B phospholipase A2, group XIIB 84647 ENSG00000138308


Database:KEGG pathway       Name:Cardiac muscle contraction       ID:04260
C=77; O=3; E=0.18; R=16.47; rawP=0.0008; adjP=0.0076
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
2  ENSG00000198689 NA SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 10479 ENSG00000198689
3  ENSG00000132681 NA ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 480 ENSG00000132681


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=3; E=0.26; R=11.33; rawP=0.0024; adjP=0.0082
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000078304 NA PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 5527 ENSG00000078304
2  ENSG00000169083 NA AR androgen receptor 367 ENSG00000169083
3  ENSG00000186298 NA PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 5501 ENSG00000186298


Database:KEGG pathway       Name:Inositol phosphate metabolism       ID:00562
C=57; O=2; E=0.13; R=14.84; rawP=0.0081; adjP=0.0230
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000038210 NA PI4K2B phosphatidylinositol 4-kinase type 2 beta 55300 ENSG00000038210
2  ENSG00000141401 NA IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 3613 ENSG00000141401


Database:KEGG pathway       Name:Renal cell carcinoma       ID:05211
C=70; O=2; E=0.17; R=12.08; rawP=0.0120; adjP=0.0291
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
2  ENSG00000135766 NA EGLN1 egl nine homolog 1 (C. elegans) 54583 ENSG00000135766


Database:KEGG pathway       Name:Phosphatidylinositol signaling system       ID:04070
C=78; O=2; E=0.18; R=10.84; rawP=0.0148; adjP=0.0300
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000038210 NA PI4K2B phosphatidylinositol 4-kinase type 2 beta 55300 ENSG00000038210
2  ENSG00000141401 NA IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 3613 ENSG00000141401


Database:KEGG pathway       Name:Hypertrophic cardiomyopathy (HCM)       ID:05410
C=83; O=2; E=0.20; R=10.19; rawP=0.0166; adjP=0.0300
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174437 NA ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 488 ENSG00000174437
2  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=7; E=2.67; R=2.62; rawP=0.0179; adjP=0.0300
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000038210 NA PI4K2B phosphatidylinositol 4-kinase type 2 beta 55300 ENSG00000038210
2  ENSG00000160216 NA AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 56894 ENSG00000160216
3  ENSG00000095380 NA NANS N-acetylneuraminic acid synthase 54187 ENSG00000095380
4  ENSG00000117592 NA PRDX6 peroxiredoxin 6 9588 ENSG00000117592
5  ENSG00000123505 NA AMD1 adenosylmethionine decarboxylase 1 262 ENSG00000123505
6  ENSG00000138308 NA PLA2G12B phospholipase A2, group XIIB 84647 ENSG00000138308
7  ENSG00000141401 NA IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 3613 ENSG00000141401




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).